Genomic Comparison of Mycobacterium avium subsp. paratuberculosis Sheep and Cattle Strains by Microarray Hybridization

Author:

Marsh Ian B.1,Bannantine John P.2,Paustian Michael L.2,Tizard Mark L.3,Kapur Vivek4,Whittington Richard J.1

Affiliation:

1. Faculty of Veterinary Science, University of Sydney, Camden, NSW, Australia

2. National Animal Disease Center, United States Department of Agriculture, Agricultural Research Service, Ames, Iowa

3. CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

4. Biomedical Genomics Center and Department of Microbiology, University of Minnesota, St. Paul, Minnesota

Abstract

ABSTRACT Microarray-based comparisons of three Mycobacterium avium subsp. paratuberculosis isolates, including one sheep strain and two cattle strains, identified three large genomic deletions in the sheep strain, totaling 29,208 bp and involving 24 open reading frames. These deletions may help explain some of the differences in pathogenicity and host specificity observed between the cattle and sheep strains of Mycobacterium avium subsp. paratuberculosis .

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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