Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens-Reference-Cited by-同舟云学术

Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens

Published:2019-06 Issue:6 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Burdet Charles¹²³,Grall Nathalie¹²⁴,Linard Morgane³,Bridier-Nahmias Antoine¹²^ORCID,Benhayoun Michèle⁵,Bourabha Khadija¹²,Magnan Mélanie¹²,Clermont Olivier¹²,d’Humières Camille¹²⁴,Tenaillon Olivier¹²,Denamur Erick¹²⁶,Massias Laurent¹²⁷,Tubiana Sarah⁵,Alavoine Loubna⁵,Andremont Antoine¹²,Mentré France¹²³,Duval Xavier¹²⁵,

Affiliation:

1. INSERM, IAME, UMR 1137, Paris, France

2. Université Paris Diderot, Sorbonne Paris Cité, Paris, France

3. AP-HP, Department of Epidemiology, Biostatistic and Clinical Research, Bichat Hospital, Paris, France

4. AP-HP, Department of Bacteriology, Bichat Hospital, Paris, France

5. INSERM Clinical Investigation Center 1425, Paris, France

6. AP-HP, Laboratory of Genetics, Bichat Hospital, Paris, France

7. AP-HP, Laboratory of Toxicology, Bichat Hospital, Paris, France

Abstract

Ceftriaxone has a higher biliary elimination than cefotaxime (40% versus 10%), which may result in a more pronounced impact on the intestinal microbiota. We performed a monocenter, randomized open-label clinical trial in 22 healthy volunteers treated by intravenous ceftriaxone (1 g/24 h) or cefotaxime (1 g/8 h) for 3 days.

Funder

Fondation pour la Recherche Médicale

Assistance Publique - Hôpitaux de Paris

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02244-18

Reference35 articles.

1. The Changing Disease-Scape in the Third Epidemiological Transition

2. Trends in Human Fecal Carriage of Extended-Spectrum β-Lactamases in the Community: Toward the Globalization of CTX-M