Genomic Epidemiology of Complex, Multispecies, Plasmid-Borne bla KPC Carbapenemase in Enterobacterales in the United Kingdom from 2009 to 2014-Reference-Cited by-同舟云学术

Genomic Epidemiology of Complex, Multispecies, Plasmid-Borne bla KPC Carbapenemase in Enterobacterales in the United Kingdom from 2009 to 2014

Published:2020-04-21 Issue:5 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Stoesser Nicole¹²^ORCID,Phan Hang T. T.²³,Seale Anna C.¹⁴,Aiken Zoie⁵,Thomas Stephanie⁵,Smith Matthew⁵,Wyllie David¹^ORCID,George Ryan⁵,Sebra Robert⁶,Mathers Amy J.⁷⁸,Vaughan Alison¹,Peto Timothy E. A.¹²⁹,Ellington Matthew J.¹⁰,Hopkins Katie L.¹⁰,Crook Derrick W.¹²⁹,Orlek Alex¹²,Welfare William¹¹,Cawthorne Julie⁵,Lenney Cheryl⁵,Dodgson Andrew⁵¹²,Woodford Neil¹⁰,Walker A. Sarah¹²⁹,

Affiliation:

1. Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

2. NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, United Kingdom

3. Faculty of Medicine, University of Southampton, Southampton, United Kingdom

4. Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom

5. Manchester University NHS Foundation Trust, Manchester, United Kingdom

6. Icahn Institute and Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, New York, USA

7. Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA

8. Clinical Microbiology Laboratory, Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA

9. NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom

10. Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI) Reference Unit, National Infection Service, Public Health England, London, United Kingdom

11. Public Health England North West, Manchester, United Kingdom

12. Public Health Laboratory, Public Heath England, Manchester, United Kingdom

Abstract

Carbapenem resistance in Enterobacterales is a public health threat. Klebsiella pneumoniae carbapenemase (encoded by alleles of the bla KPC family) is one of the most common transmissible carbapenem resistance mechanisms worldwide. The dissemination of bla KPC historically has been associated with distinct K. pneumoniae lineages (clonal group 258 [CG258]), a particular plasmid family (pKpQIL), and a composite transposon (Tn 4401 ).

Funder

Public Health England

National Institute for Health Research

NIHR | NIHR Oxford Biomedical Research Centre

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02244-19

Reference48 articles.

1. Klebsiella pneumoniae Carbapenemase (KPC)-Producing K. pneumoniae at a Single Institution: Insights into Endemicity from Whole-Genome Sequencing