Single-Locus-Sequence-Based Typing of the mgpB Gene Reveals Transmission Dynamics in Mycoplasma genitalium-Reference-Cited by-同舟云学术

Single-Locus-Sequence-Based Typing of the mgpB Gene Reveals Transmission Dynamics in Mycoplasma genitalium

Published:2020-03-25 Issue:4 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Fernández-Huerta Miguel¹^ORCID,Serra-Pladevall Judit¹,Esperalba Juliana¹,Moreno-Mingorance Albert¹,Fernández-Naval Candela¹,Barberá María-Jesús²,Aparicio David³,Pich Oscar Q.⁴⁵⁶,Pumarola Tomàs¹,Jensen Jorgen S.⁷^ORCID,Espasa Mateu¹⁴^ORCID

Affiliation:

1. Microbiology Department, Vall d´Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain

2. Sexually Transmitted Infections Unit Vall d´Hebron-Drassanes, Infectious Diseases Department, Vall d´Hebron University Hospital, University of Barcelona, Barcelona, Spain

3. Molecular Biology Institut Barcelona (IBMB-CSIC) and Maria de Maeztu Unit of Excellence, Parc Científic Barcelona, Barcelona, Spain

4. Microbiology Department, Parc Taulí University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain

5. Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Barcelona, Spain

6. Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain

7. Statens Serum Institut, Copenhagen, Denmark

Abstract

Sexually transmitted infections (STIs) by Mycoplasma genitalium are a major problem worldwide, especially given their marked and rapid propensity for developing antimicrobial resistance. Since very few treatment options exist, clinicians face an important challenge in the management of the infection. In this scenario, little is known regarding the transmission dynamics of M. genitalium and the epidemiology of antimicrobial resistance. This mgpB -based molecular typing study, conducted among 54 asymptomatically infected individuals prospectively recruited from an STI screening service, reveals two distinct epidemiological clusters that significantly correlate with sexual conduct in heterosexuals and men who have sex with men (MSM), respectively.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01886-19

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