Mycobacterium tuberculosis PPE51 Inhibits Autophagy by Suppressing Toll-Like Receptor 2-Dependent Signaling-Reference-Cited by-同舟云学术

Mycobacterium tuberculosis PPE51 Inhibits Autophagy by Suppressing Toll-Like Receptor 2-Dependent Signaling

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Strong Emily J.¹,Wang Jia¹,Ng Tony W.²,Porcelli Steven A.²³,Lee Sunhee¹⁴^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA

2. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA

3. Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA

4. Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA

Abstract

Tuberculosis is a significant global infectious disease caused by infection of the lungs with Mycobacterium tuberculosis , which resides and replicates mainly within host phagocytic cells. During coevolution with humans, Mtb has acquired various mechanisms to inhibit host cellular processes, including autophagy.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02974-21

Reference72 articles.

1. World Health Organization. 2020. Global tuberculosis report 2020.

2. Host Directed Therapies for Tuberculosis: Futures Strategies for an Ancient Disease

3. Therapeutic host-directed strategies to improve outcome in tuberculosis