PEDV-spike-protein-expressing mRNA vaccine protects piglets against PEDV challenge-Reference-Cited by-同舟云学术

PEDV-spike-protein-expressing mRNA vaccine protects piglets against PEDV challenge

Published:2024-02-14 Issue:2 Volume:15 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zhao Yongxiang¹²³⁴⁵^ORCID,Fan Baochao¹²³⁴⁵^ORCID,Song Xu¹²³,Gao Jie¹²³,Guo Rongli¹²³⁴⁵,Yi Cheng⁶,He Zhaoming⁶,Hu Hongpeng⁶,Jiang Jianhao⁶,Zhao Lixiang⁶⁷^ORCID,Zhong Tianyi⁶^ORCID,Li Bin¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China

2. Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China

3. Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China

4. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China

5. GuoTai (Taizhou) Center of Technology Innovation for Veterinary Biologicals, Taizhou, China

6. Suzhou Huiliao Biomedical Technology Co. Ltd., Suzhou, China

7. Suzhou Medical College, Soochow University, Suzhou, China

Abstract

Porcine epidemic diarrhea virus (PEDV) continues to harm the global swine industry. It is important to develop a highly effective vaccine to control PEDV infection. Here, we report a PEDV spike (S) mRNA vaccine that primes a potent antibody response and antigen-specific T-cell responses in immunized piglets. Active and passive immunization can protect piglets against PED following the virus challenge. This study highlights the efficiency of the PEDV-S mRNA vaccine and represents a viable approach for developing an efficient PEDV vaccine.

Funder

MOST | National Natural Science Foundation of China

MOST | National Key Research and Development Program of China

Jiangsu Agricultural Science and Technology Innovation Fund

Publisher

American Society for Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02958-23

Reference49 articles.

1. Porcine epidemic diarrhea virus (PEDV): An update on etiology, transmission, pathogenesis, and prevention and control

2. Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission

4. Emergence of Porcine epidemic diarrhea virus in the United States: clinical signs, lesions, and viral genomic sequences

5. Outbreak of Porcine Epidemic Diarrhea in Suckling Piglets, China

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