Aberrant Cellular Glycosylation May Increase the Ability of Influenza Viruses to Escape Host Immune Responses through Modification of the Viral Glycome-Reference-Cited by-同舟云学术

Aberrant Cellular Glycosylation May Increase the Ability of Influenza Viruses to Escape Host Immune Responses through Modification of the Viral Glycome

Published:2022-04-26 Issue:2 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Alymova Irina V.¹^ORCID,Cipollo John F.²,Parsons Lisa M.²,Music Nedzad¹³,Kamal Ram P.¹³,Tzeng Wen-Pin¹,Goldsmith Cynthia S.⁴,Contessa Joseph N.⁵⁶,Hartshorn Kevan L.⁷,Wilson Jason R.¹,Zeng Hui¹,Gansebom Shane¹⁸,York Ian A.¹

Affiliation:

1. Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization & Respiratory Diseases, Centers for Disease Control & Prevention, Atlanta, Georgia, USA

2. Food and Drug Administration, Center for Biologics Evaluation and Research, DBPAP, Silver Spring, Maryland, USA

3. Battelle Memorial Institute, Atlanta, Georgia, USA

4. Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control & Prevention, Atlanta, Georgia, USA

5. Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut, USA

6. Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut, USA

7. Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA

8. Carter Consulting, Inc., Atlanta, Georgia, USA

Abstract

People with disorders such as cancer, autoimmune disease, diabetes, or obesity often have metabolic dysregulation of cellular glycosylation and also have more severe influenza disease, a reduced immune response to the virus, and reduced vaccine efficacy. Since influenza viruses that infect such people do not show consistent genomic variations, it is generally assumed that the altered biology is mainly related to host factors.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02983-21

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