Atomic Structure of the Trichomonas vaginalis Double-Stranded RNA Virus 2

Author:

Stevens Alexander123ORCID,Muratore Katherine1,Cui Yanxiang2,Johnson Patricia J.1,Zhou Z. Hong12ORCID

Affiliation:

1. Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA

2. California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California, USA

3. Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, USA

Abstract

Trichomonas vaginalis viruses (TVVs) are double-stranded RNA (dsRNA) viruses that cohabitate in Trichomonas vaginalis , the causative pathogen of trichomoniasis, the most common nonviral sexually transmitted disease worldwide. Featuring an unsegmented dsRNA genome encoding a single capsid shell protein (CSP), TVVs contrast with multisegmented dsRNA viruses, such as the diarrhea-causing rotavirus, whose larger genome is split into 10 dsRNA segments encoding 5 unique capsid proteins.

Funder

HHS | National Institutes of Health

National Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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