A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency-Reference-Cited by-同舟云学术

A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Röling Michael¹,Mollapour Sisakht Mahsa¹²,Ne Enrico¹,Moulos Panagiotis³,Crespo Raquel¹,Stoszko Mateusz¹,De Crignis Elisa¹,Bodmer Helen¹,Kan Tsung Wai¹,Akbarzadeh Maryam¹²,Harokopos Vaggelis³,Hatzis Pantelis³,Palstra Robert-Jan¹⁴⁵,Mahmoudi Tokameh¹⁴⁵^ORCID

Affiliation:

1. Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands

2. Stem Cell and Regenerative Medicine Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran

3. Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece

4. Department of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands

5. Department of Pathology, Erasmus University Medical Center, Rotterdam, the Netherlands

Abstract

A reservoir of latently HIV-1-infected cells persists in the presence of combination antiretroviral therapy (cART), representing a major obstacle for viral eradication. Reactivation of the latent HIV-1 provirus is part of curative strategies which aim to promote clearance of the infected cells.

Funder

FP7 Ideas: European Research Council

Dutch Aidsfonds

ErasmusMC

Health Holland/Aidsfonds

ZonMW/Aidsfonds

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02980-21