A Histoplasma capsulatum Lipid Metabolic Map Identifies Antifungal Targets-Reference-Cited by-同舟云学术

A Histoplasma capsulatum Lipid Metabolic Map Identifies Antifungal Targets

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zamith-Miranda Daniel¹²^ORCID,Heyman Heino M.³,Burnet Meagan C.³,Couvillion Sneha P.³,Zheng Xueyun³,Munoz Nathalie⁴,Nelson William C.³^ORCID,Kyle Jennifer E.³,Zink Erika M.³,Weitz Karl K.³,Bloodsworth Kent J.³,Clair Geremy³^ORCID,Zucker Jeremy D.³^ORCID,Teuton Jeremy R.³,Payne Samuel H.⁵^ORCID,Kim Young-Mo³^ORCID,Reyes Gil Morayma⁶,Baker Erin S.⁷,Bredeweg Erin L.⁴,Nosanchuk Joshua D.¹²,Nakayasu Ernesto S.³^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA

2. Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA

3. Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA

4. Environmental and Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, USA

5. Department of Biology, Brigham Young University, Provo, Utah, USA

6. Hematology Laboratory, Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA

7. Department of Chemistry, North Carolina State University, Raleigh, North Carolina, USA

Abstract

It is estimated that 150 people die per hour due to the insufficient therapeutic treatments to combat fungal infections. A major hurdle to developing antifungal therapies is the scarce knowledge on the fungal metabolic pathways and mechanisms of virulence.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Environmental Health Sciences

DOE | NNSA | LDRD | Pacific Northwest National Laboratory

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02972-21

Reference66 articles.

1. Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision