Cryptococcus neoformans Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model-Reference-Cited by-同舟云学术

Cryptococcus neoformans Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model

Published:2019-04-30 Issue:2 Volume:10 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Colombo Ana Caroline¹²³,Rella Antonella³,Normile Tyler³,Joffe Luna S.³⁴,Tavares Patricia M.²,de S. Araújo Glauber R.⁵,Frases Susana⁵,Orner Erika P.³,Farnoud Amir M.³⁶,Fries Bettina C.³⁷,Sheridan Brian³,Nimrichter Leonardo²,Rodrigues Marcio L.²⁸^ORCID,Del Poeta Maurizio³⁷⁹

Affiliation:

1. Instituto de Bioquímica Médica (IBqM), Rio de Janeiro, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

2. Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

3. Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA

4. Centro de Desenvolvimento Tecnológico em Saúde (CDTS), Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

5. Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

6. Chemical and Biomolecular Engineering Department, Ohio University, Athens, Ohio, USA

7. Department of Medicine, Division of Infectious Diseases, Stony Brook University, Stony Brook, New York, USA

8. Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil

9. Veterans Administration Medical Center, Northport, New York, USA

Abstract

The number of deaths from cryptococcal meningitis is around 180,000 per year. The disease is the second leading cause of mortality among individuals with AIDS. Antifungal treatment is costly and associated with adverse effects and resistance, evidencing the urgency of development of both therapeutic and prophylactic tools. Here we demonstrate the key roles of polysaccharide- and glycolipid-containing structures in a vaccination model to prevent cryptococcosis.

Funder

VAMC

CNPq

HHS | NIH | National Institute of Allergy and Infectious Diseases

FAPERJ

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02909-18

Reference82 articles.