A Multiorgan Trafficking Circuit Provides Purifying Selection of Listeria monocytogenes Virulence Genes

Author:

Louie Alexander1,Zhang Ting23,Becattini Simone4,Waldor Matthew K.235,Portnoy Daniel A.16

Affiliation:

1. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA

2. Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

3. Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA

4. Immunology Program, Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

5. Howard Hughes Medical Institute, Boston, Massachusetts, USA

6. Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, USA

Abstract

Listeria monocytogenes maintains capabilities for free-living growth in the environment and for intracellular replication in a wide range of hosts, including livestock and humans. Here, we characterized an enterocolitis model of foodborne L. monocytogenes infection. This work highlights a multiorgan trafficking circuit and reveals a fitness advantage for bacteria that successfully complete this cycle. Because virulence factors play critical roles in systemic dissemination and multiple bottlenecks occur as the bacterial population colonizes different tissue sites, this multiorgan trafficking circuit likely provides purifying selection of virulence genes. This study also serves as a foundation for future work using the L. monocytogenes -induced enterocolitis model to investigate the biology of L. monocytogenes in the intestinal environment.

Funder

Sarah Elizatbeth O'Brien Trust Postdoctoral Fellowship

HHS | National Institutes of Health

Cancer Research Institute

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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