Model-Based Comparative Analysis of Rifampicin and Rifabutin Drug-Drug Interaction Profile-Reference-Cited by-同舟云学术

Model-Based Comparative Analysis of Rifampicin and Rifabutin Drug-Drug Interaction Profile

Published:2021-08-17 Issue:9 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Tuloup Vianney¹²,France Mathilde¹,Garreau Romain¹²,Bleyzac Nathalie¹,Bourguignon Laurent¹²³,Tod Michel¹²³,Goutelle Sylvain¹²³^ORCID

Affiliation:

1. Hospices Civils de Lyon, Groupement Hospitalier Nord, Service de Pharmacie, Lyon, France

2. Université Lyon, Université Lyon 1, UMR CNRS 5558, Laboratoire de Biométrie et Biologie Evolutive, Villeurbanne, France

3. Université Lyon, Université Lyon 1, ISPB, Faculté de Pharmacie de Lyon, Lyon, France

Abstract

Rifamycins are widely used for treating mycobacterial and staphylococcal infections. Drug-drug interactions (DDI) caused by rifampicin (RIF) are a major issue. We used a model-based approach to predict the magnitude of DDI with RIF and rifabutin (RBT) for 217 cytochrome P450 (CYP) substrates. On average, DDI caused by low-dose RIF were twice as potent as those caused by RBT. Contrary to RIF, RBT appears unlikely to cause severe DDI, even with sensitive CYP substrates.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01043-21

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