Identification of Functional MKK3/6 and MEK1/2 Homologs from Echinococcus granulosus and Investigation of Protoscolecidal Activity of Mitogen-Activated Protein Kinase Signaling Pathway Inhibitors In Vitro and In Vivo-Reference-Cited by-同舟云学术

Identification of Functional MKK3/6 and MEK1/2 Homologs from Echinococcus granulosus and Investigation of Protoscolecidal Activity of Mitogen-Activated Protein Kinase Signaling Pathway Inhibitors In Vitro and In Vivo

Published:2019-01 Issue:1 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zhang Chuanshan¹²,Li Jing³,Aji Tuerganaili⁴,Li Liang¹,Bi Xiaojuan¹,Yang Ning¹,Li Zhide²,Wang Hui¹,Mao Rui⁵,Lü Guodong¹,Shao Yingmei⁴,Vuitton Dominique A.⁶,Wen Hao⁴,Lin Renyong¹²

Affiliation:

1. State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China

2. Xinjiang Key Laboratory of Echinococcosis, WHO-Collaborating Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China

3. Basic Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China

4. Department of Hepatic Echinococcosis and Hepatobiliary Surgery, Digestive and Vascular Surgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China

5. Department of Radiation Oncology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China

6. WHO-Collaborating Centre for the Prevention and Treatment of Human Echinococcosis, Department of Parasitology, University Bourgogne Franche-Comté (EA 3181) and University Hospital, Besançon, France

Abstract

Cystic echinococcosis is a zoonosis caused by the larval stage of Echinococcus granulosus sensu lato . There is an urgent need to develop new drugs for the treatment of this disease.

Funder

Xinjiang Uygur Autonomous Region Tianshan Innovation Team Program

Xinjiang Uygur Autonomous Region Youth Science and Technology Innovation Talent Training Project-Xinjiang Outstanding Youth Natural Science Foundation Project

Xinjiang Uygur Autonomous Region Science and Technology Program

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01043-18

Reference71 articles.

1. Echinococcus granulosus infection: clinical presentation, medical treatment and outcome

2. Echinococcus granulosus: Epidemiology and state-of-the-art of diagnostics in animals

3. Role of Chemotherapeutic Agents in the Management of Cystic Echinococcosis