Patulin biosynthesis: enzymatic and nonenzymatic transformations of the mycotoxin (E)-ascladiol

Author:

Sekiguchi J,Shimamoto T,Yamada Y,Gaucher G M

Abstract

A mycotoxin, (E)-ascladiol, was established as a direct precursor of patulin in cell-free preparations of Penicillium urticae patulin-minus mutants J1 and S11, but not S15. Isomerization to a side product, (Z)-ascladiol, was nonenzymatically catalyzed by sulfhydryl compounds.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Reference19 articles.

1. Clegler A. R. W. Detroy and E. B. LUllehoj. 1971. Patulin penicillic acid and other carcinogenic lactones p. 409-434. In A. Ciegler S. Kadis and S. J. Ajl (ed.) Microbial toxins vol. 6. Academic Press Inc. New York.

2. 6-Methylsalicylic acid synthetase from Penicillium patulum;Dlmroth P.;Eur. J. Biochem.,1976

3. Conversion of 6-methyl salicylic acid into patulin by Penicillium urticae;Forrester P. I.;Biochemistry,1972

4. m-Hydroxybenzyl alcohol dehydrogenase;Gaucder G. M.;Methods Enzymol.,1975

5. Mycotoxins-their biosynthesis in fungi: patulin and related carcinogenic lactones;Gaucber G. M.;J. Food Protect.,1979

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