Emergence of a Clinical Daptomycin-Resistant Staphylococcus aureus Isolate during Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia and Osteomyelitis

Author:

Marty Francisco M.123,Yeh Wendy W.13,Wennersten Christine B.4,Venkataraman Lata4,Albano Esperanza1,Alyea Edwin P.523,Gold Howard S.43,Baden Lindsey R.123,Pillai Satish K.43

Affiliation:

1. Division of Infectious Diseases

2. Dana-Farber Cancer Institute

3. Harvard Medical School, Boston, Massachusetts

4. Division of Infectious Diseases, Beth Israel Deaconess Medical Center

5. Division of Medical Oncology, Brigham & Women's Hospital

Abstract

ABSTRACT The emergence of a clinically daptomycin-resistant Staphylococcus aureus isolate occurred during treatment of methicillin-resistant S. aureus bacteremia and probable vertebral osteomyelitis. The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-field gel electrophoresis. Daptomycin nonsusceptibility was confirmed by MIC and time-kill curve analyses.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference17 articles.

1. Arbeit, R. D., D. Maki, F. P. Tally, E. Campanaro, and B. I. Eisenstein. 2004. The safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections. Clin. Infect. Dis.38:1673-1681.

2. Carpenter, C. F., and H. F. Chambers. 2004. Daptomycin: another novel agent for treating infections due to drug-resistant gram-positive pathogens. Clin. Infect. Dis.38:994-1000.

3. Center for Drug Evaluation and Research Food and Drug Administration. 15December 2003 posting date. NDA 21-572 Cubicin TM (daptomycin for injection). [Online.] http://www.fda.gov/cder/foi/nda/2003/21-572_Cubicin_Microbr_P2.pdf . Accessed 12 June 2005.

4. Clinical and Laboratory Standards Institute. 2005. Performance standards for antimicrobial susceptibility testing; fifteenth informational supplement M100-S15. Clinical and Laboratory Standards Institute Wayne Pa.

5. Cubist Pharmaceuticals Inc. 2003 posting date. Cubicin TM (daptomycin for Injection) prescriber information. [Online.] http://www.cubicin.com/documents/cubicin_large_pi.pdf . Accessed 12 June 2005.

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