Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants

Author:

Pitts Jared1,Li Jiani1,Perry Jason K.1,Du Pont Venice1,Riola Nicholas1,Rodriguez Lauren1,Lu Xianghan1,Kurhade Chaitanya2,Xie Xuping2ORCID,Camus Gregory1,Manhas Savrina1,Martin Ross1,Shi Pei-Yong2,Cihlar Tomas1,Porter Danielle P.1,Mo Hongmei1,Maiorova Evguenia1,Bilello John P.1ORCID

Affiliation:

1. Gilead Sciences, Inc., Foster City, California, USA

2. Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA

Abstract

Genetic variation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence and rapid spread of multiple variants throughout the pandemic, of which Omicron is currently the predominant variant circulating worldwide. SARS-CoV-2 variants of concern/variants of interest (VOC/VOI) have evidence of increased viral transmission, disease severity, or decreased effectiveness of vaccines and neutralizing antibodies.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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