Mutations in 16S rRNA and Ribosomal Protein S5 Associated with High-Level Spectinomycin Resistance in Pasteurella multocida-Reference-Cited by-同舟云学术

Mutations in 16S rRNA and Ribosomal Protein S5 Associated with High-Level Spectinomycin Resistance in Pasteurella multocida

Published:2007-06 Issue:6 Volume:51 Page:2244-2246
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kehrenberg Corinna¹,Schwarz Stefan¹

Affiliation:

1. Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), Höltystr. 10, 31535 Neustadt-Mariensee, Germany

Abstract

ABSTRACT Pasteurella multocida isolates with high-level spectinomycin resistance in which no adenyltransferase genes could be demonstrated exhibited a C1192G transversion in the 16S rRNA of all six or five of the six rRNA operons and/or two different types of 3-bp deletions in the rpsE gene that codes for the ribosomal protein S5.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00229-07

Reference21 articles.

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4. Davies, C., D. E. Bussiere, B. L. Golden, S. J. Porter, V. Ramakrishnan, and S. W. White. 1998. Ribosomal proteins S5 and L6: high resolution crystal structures and roles in protein biosynthesis and antibiotic resistance. J. Mol. Biol.279:873-888.

5. De Stasio, E. A., D. Moazed, H. F. Noller, and A. E. Dahlberg. 1989. Mutations in 16S ribosomal RNA disrupt antibiotic-RNA interactions. EMBO J.8:1213-1216.

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