Punicalagin, an Inhibitor of Sortase A, Is a Promising Therapeutic Drug to Combat Methicillin-Resistant Staphylococcus aureus Infections-Reference-Cited by-同舟云学术

Punicalagin, an Inhibitor of Sortase A, Is a Promising Therapeutic Drug to Combat Methicillin-Resistant Staphylococcus aureus Infections

Published:2022-06-21 Issue:6 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Song Wu¹^ORCID,Wang Li¹,Jin Mengli¹,Guo Xuerui¹²,Wang Xingye¹,Guan Jiyu³,Zhao Yicheng¹⁴^ORCID

Affiliation:

1. College of Clinical Medicine, Changchun University of Chinese Medicine, Changchun, China

2. School of Pharmacy, Jilin University, Changchun, China

3. Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China

4. Center for Pathogen Biology and Infectious Diseases, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China

Abstract

Antimicrobial resistance (AMR) poses a major threat to human health globally. Staphylococcus aureus is recognized as a cause of disease worldwide, especially methicillin-resistant S. aureus (MRSA) and vancomycin-resistant S. aureus (VRSA). The enzyme sortase A (SrtA), present on the cell surface of S. aureus , plays a key role in bacterial virulence without affecting the bacterial viability, and SrtA-deficient S. aureus strains do not affect the growth of bacteria.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00224-22

Reference47 articles.

1. Antimicrobial resistance in gram-positive bacteria

2. Neutrophils in innate host defense against Staphylococcus aureus infections

3. A review on nanosystems as an effective approach against infections of Staphylococcus aureus