High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression

Author:

Poirson Juline1,Suarez Irina Paula2,Straub Marie-Laure1,Cousido-Siah Alexandra2,Peixoto Paul3,Hervouet Eric3,Foster Anne1,Mitschler André2,Mukobo Noella1,Chebaro Yassmine2,Garcin Dominique4ORCID,Recberlik Sevda5,Gaiddon Christian5,Altschuh Danièle2,Nominé Yves2,Podjarny Alberto2,Trave Gilles2,Masson Murielle1ORCID

Affiliation:

1. Equipe Signalisation Nucléaire, UMR 7242, CNRS, Université de Strasbourg, Ecole Supérieure de Biotechnologie de Strasbourg (ESBS), Illkirch, France

2. Equipe Labellisée Ligue 2015, Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U1258, CNRS UMR 7104, Université de Strasbourg, Illkirch, France

3. Equipe TIM-C, groupe “Autophagy, EMT and antitumor T-cell immunity,” INSERM UMR1098, Laboratoire de Biochimie, Besançon, France

4. Department of Microbiology and Molecular Medicine, University of Geneva School of Medicine, Geneva, Switzerland

5. Equipe Streinth, INSERM U1113, Strasbourg, France

Abstract

Persistent HPV infections can be associated with the development of several cancers. The ability to persist depends on the ability of the virus to escape the host immune system.

Funder

Ligue Contre le Cancer

HHS | NIH | OSC | Common Fund

Fondation pour la Recherche Médicale

Agence Nationale de la Recherche

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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