Hidden VIM-1 Metallo-β-Lactamase Phenotypes among Acinetobacter baumannii Clinical Isolates-Reference-Cited by-同舟云学术

Hidden VIM-1 Metallo-β-Lactamase Phenotypes among Acinetobacter baumannii Clinical Isolates

Published:2008-01 Issue:1 Volume:46 Page:346-349
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Ikonomidis Alexandros¹,Ntokou Eleni¹,Maniatis Antonios N.¹,Tsakris Athanassios²,Pournaras Spyros¹

Affiliation:

1. Department of Microbiology, Medical School, University of Thessaly, Larissa

2. Department of Microbiology, Medical School, University of Athens, Athens, Greece

Abstract

ABSTRACT A total of 87 Acinetobacter baumannii nonrepetitive consecutive clinical isolates were tested for the presence of metallo-β-lactamases (MBLs). Results of phenotypic assays (MBL Etest, imipenem/imipenem-EDTA combined-disk test, and imipenem/EDTA double-disk synergy test) were negative in all cases, but molecular testing revealed the presence of two bla VIM-1 -carrying isolates. One isolate had bla VIM-1 preceded by a weak P1 promoter, and both had inactivated P2 promoters and reduced bla VIM-1 expression, partially justifying the results revealing hidden MBL phenotypes.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01670-07

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