HSPA5 Promotes Attachment and Internalization of Porcine Epidemic Diarrhea Virus through Interaction with the Spike Protein and the Endo-/Lysosomal Pathway

Author:

Zhou Chuanjie12,Liu Yunchao2,Wei Qiang2,Chen Yumei3,Yang Suzhen2,Cheng Anchun1ORCID,Zhang Gaiping1234ORCID

Affiliation:

1. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China

2. Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, China

3. School of Life Sciences, Zhengzhou University, Zhengzhou, China

4. Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou University, Yangzhou, China

Abstract

PEDV infection causes severe piglet mortality and threatens the global pig industry. However, the complex invasion mechanism of PEDV makes its prevention and control difficult.

Funder

MOST | National Key Research and Development Program of China

The independent innovation reserch project of Henan Academy of Agricultural sciences

The independent innovation reserch project of Henan academy of Agricultural Sciences

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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