The Susceptibility of Primate Lentiviruses to Nucleosides and Vpx during Infection of Dendritic Cells Is Regulated by CA-Reference-Cited by-同舟云学术

The Susceptibility of Primate Lentiviruses to Nucleosides and Vpx during Infection of Dendritic Cells Is Regulated by CA

Published:2015-04 Issue:7 Volume:89 Page:4030-4034
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Barateau Véronique¹²³⁴⁵,Nguyen Xuan-Nhi¹²³⁴⁵,Bourguillault Fanny¹²³⁴⁵,Berger Grégory¹²³⁴⁵,Cordeil Stéphanie¹²³⁴⁵,Cimarelli Andrea¹²³⁴⁵

Affiliation:

1. Centre International de Recherche en Infectiologie (CIRI), Lyon, France

2. INSERM, U1111, Lyon, France

3. Ecole Normale Supérieure de Lyon, Lyon, France

4. CNRS, UMR5308, Lyon, France

5. University of Lyon, Lyon I, UMS3444/US8 BioSciences Gerland, Lyon, France

Abstract

ABSTRACT The block toward human immunodeficiency virus type 1 (HIV-1) infection of dendritic cells (DCs) can be relieved by Vpx (viral protein X), which degrades sterile alpha motif-hydroxylase domain 1 (SAMHD1) or by exogenously added deoxynucleosides (dNs), lending support to the hypothesis that SAMHD1 acts by limiting deoxynucleoside triphosphates (dNTPs). This notion has, however, been questioned. We show that while dNs and Vpx increase the infectivity of HIV-1, only the latter restores the infectivity of a simian immunodeficiency virus of macaques variant, SIV MAC ΔVpx virus. This distinct behavior seems to map to CA, suggesting that species-specific CA interactors modulate infection of DCs.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.03315-14

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