Establishment, Validation, and Application of a New World Primate Model of Enterotoxigenic Escherichia coli Disease for Vaccine Development

Author:

Rollenhagen Julianne E.1,Jones Franca2,Hall Eric2,Maves Ryan2,Nunez Gladys2,Espinoza Nereyda2,O'Dowd Aisling1,Prouty Michael G.1,Savarino Stephen J.13

Affiliation:

1. Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA

2. Bacteriology Department, Naval Medical Research Unit No. 6, Lima, Peru

3. Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

Abstract

The establishment of an animal model that closely approximates enterotoxigenic Escherichia coli (ETEC) disease in humans is critical for the development and evaluation of vaccines against this enteropathogen. Here, we evaluated the susceptibility of Aotus nancymaae , a New World monkey species, to ETEC infection.

Funder

Military Infectious Diseases Research Program

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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