Effects of Ovarian Steroids on Immunoglobulin-Secreting Cell Function in Healthy Women-Reference-Cited by-同舟云学术

Effects of Ovarian Steroids on Immunoglobulin-Secreting Cell Function in Healthy Women

Published:2003-09 Issue:5 Volume:10 Page:944-949
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Lü Fabien X.¹²,Ma Zhongmin¹,Moser Susie³,Evans Thomas G.³,Miller Christopher J.¹²⁴

Affiliation:

1. California National Primate Research Center

2. Center for Comparative Medicine

3. Department of Internal Medicine, School of Medicine, University of California—Davis, Davis, California 95616

4. Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine

Abstract

ABSTRACT To determine the effect of the ovarian hormone cycle on immunity, immunoglobulin-secreting cell (ISC) frequency and lymphocyte subsets were examined in the blood of healthy women. We found that immunoglobulin A (IgA)-secreting cells (IgA-ISC) were fourfold more frequent than IgG-ISC in peripheral blood mononuclear cells (PBMC). Further, the ISC frequency in PBMC was highest ( P < 0.05) during the periovulatory stage of the menstrual cycle. Thus, endogenous ovarian steroids regulate the ISC frequency and this may explain why women are more resistant to viral infections and tend to have more immune-mediated diseases than men do.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CDLI.10.5.944-949.2003

Reference36 articles.

1. Amadori, A., R. Zamarchi, G. De Silvestro, G. Forza, G. Cavatton, G. A. Danieli, M. Clementi, and L. Chieco-Bianchi. 1995. Genetic control of the CD4/CD8 T-cell ratio in humans. Nat. Med.1:1279-1283.

2. Ansar, A. S., W. J. Penhale, and N. Talal. 1985. Sex hormones, immune responses and autoimmune diseases. Am. J. Pathol.121:531-551.

3. Barna, M., T. Komatsu, Z. Bi, and C. S. Reiss. 1996. Sex differences in susceptibility to viral infection of the central nervous system. J. Neuroimmunol.67:31-39.

4. Bouley, D. M., S. Kanangat, W. Wire, and B. T. Rouse. 1995. Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-γ knockout mice. J. Immunol.155:3964-3971.

5. Cannon, J. G., and C. A. Dinarello. 1985. Increased plasma interleukin-1 activity in women after ovulation. Science227:1247-1249.

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Neutral douche: a hydrotherapeutic tool to manage pain and systemic symptoms in primary dysmenorrhea - a randomised controlled study;Journal of Complementary and Integrative Medicine;2020-10-12

2. The role of the ovarian cycle and the effects of mitogen-induced cytokines on human prolactin gene expression in peripheral blood mononuclear cells;Endocrine Research;2017-10-03

3. Characterization of the cervical mucus plug in mares;Reproduction;2017-02

4. A randomized clinical trial on the effects of progestin contraception in the genital tract of HIV-infected and uninfected women in Lilongwe, Malawi: Addressing evolving research priorities;Contemporary Clinical Trials;2017-01

5. Chlamydia trachomatis Genital Tract Infections: When Host Immune Response and the Microbiome Collide;Trends in Microbiology;2016-09