Identification of an Intramolecular Switch That Controls the Interaction of Helicase nsp10 with Membrane-Associated nsp12 of Porcine Reproductive and Respiratory Syndrome Virus-Reference-Cited by-同舟云学术

Identification of an Intramolecular Switch That Controls the Interaction of Helicase nsp10 with Membrane-Associated nsp12 of Porcine Reproductive and Respiratory Syndrome Virus

Published:2021-08-10 Issue:17 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Hu Yunhao¹,Ke Purui¹,Gao Peng¹,Zhang Yongning¹,Zhou Lei¹,Ge Xinna¹,Guo Xin¹^ORCID,Han Jun¹^ORCID,Yang Hanchun¹

Affiliation:

1. Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of China

Abstract

Assembly of replication and transcription complexes (RTC) is a limiting step for viral RNA synthesis. The PRRSV RTC macromolecular complexes are comprised of mainly viral nonstructural replicase proteins (nsps), but how they come together remains elusive.

Funder

Agriculture Research System of China

NSFC | China National Funds for Distinguished Young Scientists

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00518-21

Reference62 articles.

1. The Nonstructural Proteins Directing Coronavirus RNA Synthesis and Processing