Pathobiology of an NS1-Truncated H3N2 Swine Influenza Virus Strain in Pigs-Reference-Cited by-同舟云学术

Pathobiology of an NS1-Truncated H3N2 Swine Influenza Virus Strain in Pigs

Published:2022-06-08 Issue:11 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Vandoorn Elien¹^ORCID,Stadejek Wojciech¹,Parys Anna¹,Chepkwony Sharon¹,Chiers Koen²,Van Reeth Kristien¹

Affiliation:

1. Laboratory of Virology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium

2. Laboratory of Veterinary Pathology, Department of Pathobiology, Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium

Abstract

Swine influenza A viruses (swIAVs) with a truncated NS1del126 protein were strongly attenuated in previous laboratory-based safety studies and therefore approved for use as LAIVs for swine in the United States. In the field, however, the LAIV strains were detected in diagnostic samples and could regain a wild-type NS1 via reassortment with endemic swIAVs.

Funder

UGent | Bijzonder Onderzoeksfonds UGent

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00519-22

Reference38 articles.

1. Surveillance of European Domestic Pig Populations Identifies an Emerging Reservoir of Potentially Zoonotic Swine Influenza A Viruses

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3. The global antigenic diversity of swine influenza A viruses

4. Reassortment Patterns in Swine Influenza Viruses

5. Vaccines and vaccination for swine influenza: differing situations in Europe and the USA

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