SARS-CoV-2 nsp13 Restricts Episomal DNA Transcription without Affecting Chromosomal DNA

Author:

Li Aixin12,Zhang Bei1,Zhao Kaitao1ORCID,Yin Zhinang3,Teng Yan1,Zhang Lu1,Xu Zaichao1,Liang Kaiwei3,Cheng Xiaoming145,Xia Yuchen1ORCID

Affiliation:

1. State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Hubei Jiangxia Laboratory, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China

2. School of Medical Laboratory, Weifang Medical University, Weifang, China

3. Department of Pathophysiology, TaiKang Medical School, Wuhan University, Wuhan, China

4. Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China

5. Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China

Abstract

To combat COVID-19, we need to understand SARS-CoV-2 and develop effective antiviral drugs. In our study, we serendipitously found that SARS-CoV-2 nsp13 could suppress episomal DNA transcription without affecting chromosomal DNA.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Host factors of SARS-CoV-2 in infection, pathogenesis, and long-term effects;Frontiers in Cellular and Infection Microbiology;2024-05-22

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