Multiple Viral Protein Genome-Linked Proteins Compensate for Viral Translation in a Positive-Sense Single-Stranded RNA Virus Infection

Author:

Warsaba Reid12,Stoynov Nikolay13,Moon Kyung-Mee13,Flibotte Stephane4,Foster Leonard13ORCID,Jan Eric12ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

2. Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada

3. Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

4. UBC/LSI Bioinformatics Facility, University of British Columbia, Vancouver, British Columbia, Canada

Abstract

Genetic duplication is exceedingly rare in small RNA viral genomes, as there is selective pressure to prevent RNA genomes from expanding. However, some small RNA viruses encode multiple copies of a viral protein, most notably an unusual viral protein that is linked to the viral RNA genome.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Genome Canada

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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