Mammalian Transforming Growth Factor β1 Activated after Ingestion by Anopheles stephensi Modulates Mosquito Immunity-Reference-Cited by-同舟云学术

Mammalian Transforming Growth Factor β1 Activated after Ingestion by Anopheles stephensi Modulates Mosquito Immunity

Published:2003-06 Issue:6 Volume:71 Page:3000-3009
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Luckhart Shirley¹,Crampton Andrea L.¹,Zamora Ruben²,Lieber Matthew J.¹,Dos Santos Patricia C.¹,Peterson Tina M. L.¹,Emmith Nicole¹,Lim Junghwa¹,Wink David A.³,Vodovotz Yoram²

Affiliation:

1. Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061

2. Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15260

3. Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland 20892

Abstract

ABSTRACT During the process of bloodfeeding by Anopheles stephensi , mammalian latent transforming growth factor β1 (TGF-β1) is ingested and activated rapidly in the mosquito midgut. Activation may involve heme and nitric oxide (NO), agents released in the midgut during blood digestion and catalysis of l- arginine oxidation by A. stephensi NO synthase (AsNOS). Active TGF-β1 persists in the mosquito midgut to extended times postingestion and is recognized by mosquito cells as a cytokine. In a manner analogous to the regulation of vertebrate inducible NO synthase and malaria parasite ( Plasmodium ) infection in mammals by TGF-β1, TGF-β1 regulates AsNOS expression and Plasmodium development in A. stephensi . Together, these observations indicate that, through conserved immunological cross talk, mammalian and mosquito immune systems interface with each other to influence the cycle of Plasmodium development.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.71.6.3000-3009.2003

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