Affiliation:
1. Department of Molecular Biology and Microbiology, Tufts University, School of Medicine, Boston, Massachusetts
Abstract
ABSTRACT
Some cholate derivatives that are normal components of bile can act with glycine to induce the germination of
Clostridium difficile
spores, but at least one bile component, chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate inhibits the germination of
C. difficile
spores in response to cholate and taurocholate.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference18 articles.
1. Akoachere, M., R. C. Squires, A. M. Nour, L. Angelov, J. Brojatsch, and E. Abel-Santos. 2007. Identification of an in vivo inhibitor of Bacillus anthracis spore germination. J. Biol. Chem. 282 : 12112-12118.
2. Dawson, A. M., D. Trenchard, and A. Guz. 1965. Small bowel tonometry: assessment of small gut mucosal oxygen tension in dog and man. Nature 206 : 943-944.
3. Freeman, J., and M. H. Wilcox. 1999. Antibiotics and Clostridium difficile. Microbes Infect. 1 : 377-384.
4. Gerding, D. N., C. A. Muto, and J. R. C. Owens. 2008. Treatment of Clostridium difficile infection. Clin. Infect. Dis. 46 : S32-S42.
5. Hamilton, J. P., G. Xie, J.-P. Raufman, S. Hogan, T. L. Griffin, C. A. Packard, D. A. Chatfield, L. R. Hagey, J. H. Steinbach, and A. F. Hofmann. 2007. Human cecal bile acids: concentration and spectrum. Am. J. Physiol. Gastrointest. Liver Physiol. 293 : G256-G263.
Cited by
175 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献