Expression of CD117 (c-Kit) on Circulating B Cells in Pediatric Schistosomiasis-Reference-Cited by-同舟云学术

Expression of CD117 (c-Kit) on Circulating B Cells in Pediatric Schistosomiasis

Published:2022-08-18 Issue:8 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Onkanga Isaac O.¹²,Hamilton Rachael³,Mwinzi Pauline N. M.¹,Schneider Thomas³,Ondigo Bartholomew N.¹⁴,Sang Huldah¹,Ondari Edna¹,Rawago Fredrick¹,Jaoko Walter²,Odiere Maurice R.¹,Ganley-Leal Lisa³^ORCID

Affiliation:

1. Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya

2. KAVI-Institute of Clinical Research, and Department of Medical Microbiology & Immunology, University of Nairobi, Kenya

3. Elegance Biotechnologies, LLC, Wayne, Pennsylvania, USA

4. Department of Biochemistry and Molecular Biology, Egerton University, Nakuru, Kenya

Abstract

Few B cells express CD27, the primary marker for memory B cells, in pediatric schistosomiasis, suggesting B cell malfunction. This study further demonstrates unexpected high expression of CD117 on circulating B cells in children highly exposed toSchistosoma mansoniinfectious larvae.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00160-22

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