Development of a Monoclonal Antibody to a Vibriophage as a Proxy for Vibrio cholerae Detection-Reference-Cited by-同舟云学术

Development of a Monoclonal Antibody to a Vibriophage as a Proxy for Vibrio cholerae Detection

Published:2022-08-18 Issue:8 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Sayeed Md Abu¹^ORCID,Paisie Taylor²,Alam Meer Taifur³,Ali Afsar¹³,Camilli Andrew⁴,Wrammert Jens⁵^ORCID,Khan Ashraful Islam⁶,Qadri Firdausi⁶,Salemi Marco²^ORCID,Morris J. Glenn³^ORCID,Nelson Eric J.¹³⁷^ORCID

Affiliation:

1. Department of Environmental and Global Health, University of Florida, Gainesville, Florida, USA

2. Department of Pathology, University of Florida, Gainesville, Florida, USA

3. Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA

4. Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA

5. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

6. International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh

7. Department of Pediatrics, University of Florida, Gainesville, Florida, USA

Abstract

Cholera is an acute watery, diarrheal disease that causes high rates of morbidity and mortality without treatment. Early detection of the etiologic agent of toxigenicVibrio choleraeis important to mobilize treatment and mitigate outbreaks. Monoclonal antibody (mAb) based rapid diagnostic tests (RDTs) enable early detection in settings without laboratory capacity. However, the odds of an RDT testing positive are reduced by nearly 90% when the common virulent bacteriophage ICP1 is present.

Funder

HHS | NIH | OSC | Common Fund

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00161-22

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