A Candidate Bacterial-Type Amino Acid Decarboxylase Is Essential for Male Gamete Exflagellation and Mosquito Transmission of the Malaria Parasite-Reference-Cited by-同舟云学术

A Candidate Bacterial-Type Amino Acid Decarboxylase Is Essential for Male Gamete Exflagellation and Mosquito Transmission of the Malaria Parasite

Published:2023-07-18 Issue:7 Volume:91 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kina Umit Y.¹²,Kamil Mohd¹³,Deveci Gozde¹,Rafiqi Ab. Matteen¹^ORCID,Matuschewski Kai⁴,Aly Ahmed S. I.¹⁵^ORCID

Affiliation:

1. Aly lab, Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Istanbul, Turkey

2. Department of Biotechnology, Institute of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey

3. Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA

4. Department of Molecular Parasitology, Institute of Biology, Humboldt University, Berlin, Germany

5. School of Science and Engineering, Al Akhawayn University, Ifrane, Morocco

Abstract

A frequent side effect of chemotherapy against malaria parasite blood infections is a dramatic induction of the sexual blood stages, thereby enhancing the risk of future malaria transmissions. The polyamine biosynthesis pathway has been suggested as a candidate target for transmission-blocking anti-malarial drug development.

Funder

TUBITAK

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00167-23

Reference43 articles.

1. Regulation of Sexual Commitment and Gametocytogenesis in Malaria Parasites

2. SUBMICROSCOPIC PLASMODIUM FALCIPARUM GAMETOCYTE DENSITIES FREQUENTLY RESULT IN MOSQUITO INFECTION

3. Chloroquine increases Plasmodium falciparum gametocytogenesis in vitro

4. Risk factors for gametocyte carriage in Gambian children.

5. Transmission-Blocking Strategies Against Malaria Parasites During Their Mosquito Stages