Frequency of Voriconazole ResistanceIn Vitroamong Spanish Clinical Isolates ofCandidaspp. According to Breakpoints Established by the Antifungal Subcommittee of the European Committee on Antimicrobial Susceptibility Testing

Abstract

ABSTRACTA total of 4,226 Spanish clinical isolates ofCandidaspp. were analyzed to assess resistance to voriconazole according to breakpoints established by the European Committee for Antimicrobial Susceptibility Testing (where susceptibility [S] to voriconazole corresponds to a MIC of ≤0.12 mg/liter). Resistance was uncommon amongCandida albicans(5%),C. parapsilosis(1.2%), andC. tropicalis(11%) isolates. Voriconazole MICs of >0.12 mg/liter were more frequent amongCandida glabrataandC. kruseiisolates. A significant percentage of voriconazole-resistant strains came from oropharyngeal infections and exhibited high MICs of other azoles.