Attenuation of Getah Virus by a Single Amino Acid Substitution at Residue 253 of the E2 Protein that Might Be Part of a New Heparan Sulfate Binding Site on Alphaviruses-Reference-Cited by-同舟云学术

Attenuation of Getah Virus by a Single Amino Acid Substitution at Residue 253 of the E2 Protein that Might Be Part of a New Heparan Sulfate Binding Site on Alphaviruses

Published:2022-03-23 Issue:6 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wang Ningning¹,Zhai Xiaofeng¹,Li Xiaoling¹,Wang Yu¹,He Wan-Ting¹,Jiang Zhiwen¹,Veit Michael²,Su Shuo¹^ORCID

Affiliation:

1. Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China

2. Institute for Virology, Center for Infection Medicine, Veterinary Faculty, Free University Berlin, Berlin, Germany

Abstract

Due to decades of inadequate monitoring and lack of vaccines and specific treatment, a large number of people have been infected with alphaviruses. GETV is a re-emerging alphavirus that has the potential to infect humans.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01751-21

Reference48 articles.

1. From discovery to spread: The evolution and phylogeny of Getah virus

2. Getah Virus as an Equine Pathogen

3. Epizootiological Investigation of Getah Virus Infection among Racehorses in Japan in 2014