Interferon Production in Mixed Lymphocyte Cell Cultures

Author:

Gifford George E.1,Tibor Agnes1,Peavy Duane L.1

Affiliation:

1. Department of Immunology and Medical Microbiology, University of Florida College of Medicine, Gainesville, Florida 32601

Abstract

Mixed lymphocyte cultures from mice with marked differences in major and minor histocompatibility antigens were found to produce an inhibitor of viral replication with properties of interferon. Cultures produced maximal amounts of interferon at approximately 72 to 96 hr, a time when maximal stimulation of deoxyribonucleic acid synthesis also occurred.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference13 articles.

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2. Leukocytes and interferon in the host response to viral infection. II. Enhanced interferon response of leukocytes from immune animals;Glascow L. A.;J. Bacteriol.,1966

3. Immune specific induction of interferon production in cultures of human blood Iymphocytes;Green J. A.;Science,1969

4. Induction of interferon by Iymphoblastoid cell lines;Haase A. T.;Proc. Soc. Exp. Biol. Med.,1970

5. Inhibition of TRIC agents by virus-induced interferons;Hanna L.;Proc. Soc. Exp. Biol. Med.,1966

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