Mouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3-Reference-Cited by-同舟云学术

Mouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3

Published:2008-05 Issue:5 Volume:52 Page:1876-1879
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hinrichsen Kerstin¹,Podschun Rainer²,Schubert Sabine²,Schröder Jens M.¹,Harder Jürgen¹,Proksch Ehrhardt¹

Affiliation:

1. Department of Dermatology

2. Institute for Infection Medicine, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany

Abstract

ABSTRACT Searching the database for mouse homologs of the antimicrobial peptide human beta-defensin-3 (hBD-3) revealed highest identity (69%) to mouse beta-defensin-14 (mBD-14). Recombinant mBD-14 exhibited broad-spectrum, nanomolar microbicidal activity. Treatment of keratinocytes with gamma interferon or transforming growth factor alpha increased mBD-14 gene expression. These data suggest that mBD-14 is the functional ortholog of hBD-3.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01308-07

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