Bactericidal/Permeability-Increasing Protein Prevents Mucosal Damage in an Experimental Rat Model of Chronic Otitis Media with Effusion-Reference-Cited by-同舟云学术

Bactericidal/Permeability-Increasing Protein Prevents Mucosal Damage in an Experimental Rat Model of Chronic Otitis Media with Effusion

Published:2000-05 Issue:5 Volume:68 Page:2992-2994
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Nell Marja J.¹,Koerten Henk K.²,Grote Jan J.¹

Affiliation:

1. Department of Otorhinolaryngology1 and

2. Center for Electronmicroscopy,2 Leiden University Medical Center, Leiden, The Netherlands

Abstract

ABSTRACT In this study, the efficacy of bactericidal/permeability-increasing protein (BPI) was assessed in a rat model of chronic otitis media with effusion. BPI injection prevented disturbance of the mucociliary clearance system of the middle ear. Hence, it is postulated that BPI can be a new therapy for chronic otitis media with effusion.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.5.2992-2994.2000

Reference15 articles.

1. Ten-year review of otitis media pathogenesis;Bluestone C. D.;Pediatr. Infect. Dis. J.,1992

2. Experimental otitis media with effusion following middle ear inoculation of nonviable H. influenzae;DeMaria T. F.;Ann. Otol. Rhinol. Laryngol.,1984

3. Endotoxin in middle-ear effusions from patients with chronic otitis media with effusion

4. Bactericidal/permeability-increasing protein (rBPI21) in patients with hemorrhage due to trauma: results of a multicenter phase II clinical trial;Demetriades D.;J. Trauma Inj. Infect. Crit. Care,1999

5. The bactericidal/permeability-increasing protein (BPI), a potent element in host-defense against gram-negative bacteria and lipopolysaccharide;Elsbach P.;Immunobiology,1993

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