Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect-Reference-Cited by-同舟云学术

Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect

Published:1996-02 Issue:2 Volume:40 Page:488-490
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

den Hollander J G¹,Mouton J W¹,Bakker-Woudenberg I A¹,Vleggaar F P¹,van Goor M P¹,Verbrugh H A¹

Affiliation:

1. Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University Rotterdam, Netherlands.

Abstract

To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.40.2.488

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