Differential elevation of circulating interleukin-1 beta, tumor necrosis factor alpha, and interleukin-6 in AIDS-associated cachectic states

Author:

Bélec L1,Meillet D1,Hernvann A1,Grésenguet G1,Gherardi R1

Affiliation:

1. Service de Microbiologie (Virologie), Hôpital Broussais, Paris, France.

Abstract

Elevation of serum interleukin-1 beta (IL-1 beta) levels, and to a lesser degree tumor necrosis factor alpha levels, was found in cachectic human immunodeficiency virus (HIV)-infected African patients without concurrent opportunistic infection or neoplasia (HIV wasting syndrome). A heterogeneous pattern of elevations of cytokine levels, including mild elevations of IL-1 beta and pronounced elevations of IL-6 levels, was found in other cachectic states.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Reference17 articles.

1. The HIV wasting syndrome;Belec L.;Muscle Nerve,1992

2. Interleukin 1 inhibitor masks high interleukin 1 production in acquired immunodeficiency syndrome (AIDS);Berman M. A.;Clin. Immunol. Immunopathol.,1987

3. Infection with HIV is associated with elevated IL-6 levels and production;Breen E. C.;J. Immunol.,1990

4. Cox G. and J. Gauldie. 1992. Structure and function of interleukin-6 p. 97-120. In S. L. Kunkel and D. G. Remick (ed.) Cytokines in health and disease. Marcel Dekker Inc. New York.

5. Interleukin-1 and interleukin-1 antagonism;Dinarello C. A.;Blood,1991

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