Affiliation:
1. Laboratoire de Biologie Moléculaire, Département des Sciences Biologiques, Université du Québec à Montréal, Montréal, Québec H3C 3P8, Canada
Abstract
ABSTRACT
The Graffi murine leukemia virus (MuLV) is a nondefective retrovirus that induces granulocytic leukemia in BALB/c and NFS mice. To identify genes involved in Graffi MuLV-induced granulocytic leukemia, tumor cell DNAs were examined for genetic alterations at loci described as common proviral integration sites in MuLV-induced myeloid, lymphoid, and erythroid leukemias. Southern blot analysis revealed rearrangements in c-
myc
,
Fli-1
,
Pim-1
, and
Spi-1
/
PU.1
genes in 20, 10, 3.3, and 3.3% of the tumors tested, respectively. These results demonstrate for the first time the involvement of those genes in granulocytic leukemia.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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