Novel Drug Resistance Pattern Associated with the Mutations K70G and M184V in Human Immunodeficiency Virus Type 1 Reverse Transcriptase-Reference-Cited by-同舟云学术

Novel Drug Resistance Pattern Associated with the Mutations K70G and M184V in Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Published:2007-12 Issue:12 Volume:51 Page:4489-4491
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bradshaw D.¹,Malik S.²,Booth C.¹,Van Houtte M.³,Pattery T.³,Waters A.⁴,Ainsworth J.⁴,Geretti A. M.¹²

Affiliation:

1. Royal Free Hospital

2. Royal Free & University College Medical School, London, United Kingdom

3. Virco BVBA, Mechelen, Belgium

4. Department of HIV Medicine, North Middlesex University Hospital, London, United Kingdom

Abstract

ABSTRACT We describe an unusual pathway of human immunodeficiency virus type 1 reverse transcriptase resistance during therapy with tenofovir-emtricitabine, characterized initially by the mutations K70E and M184V and later by K70G and M184V, with the two mutations coexisting on the same viral genome. Phenotypic resistance to lamivudine, emtricitabine, abacavir, didanosine, and tenofovir was observed, whereas susceptibility to zidovudine and stavudine was preserved.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00687-07

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