Affiliation:
1. Department of Biology, Georgetown University, Washington, DC, USA
Abstract
ABSTRACT
Infection with
Giardia duodenalis
is one of the most common causes of diarrheal disease in the world. While numerous studies have identified important contributions of adaptive immune responses to parasite control, much less work has examined innate immunity and its connections to the adaptive response during this infection. We explored the role of complement in immunity to
Giardia
using mice deficient in mannose-binding lectin (Mbl2) or complement factor 3a receptor (C3aR). Both strains exhibited delayed clearance of parasites and a reduced ability to recruit mast cells in the intestinal submucosa. C3aR-deficient mice had normal production of antiparasite IgA, but
ex vivo
T cell recall responses were impaired. These data suggest that complement is a key factor in the innate recognition of
Giardia
and that recruitment of mast cells and activation of T cell immunity through C3a are important for parasite control.
Funder
HHS | NIH | National Institute of Allergy and Infectious Diseases
HHS | NIH | Fogarty International Center
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
23 articles.
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