Clostridioides difficile Toxin B Activates Group 3 Innate Lymphocytes

Author:

Pope Rosemary L.1,Chitrakar Alisha1,Sah Prakash1,Shadid Tyler1,Ballard Jimmy D.1ORCID,Zenewicz Lauren A.1ORCID

Affiliation:

1. Department of Microbiology and Immunology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

Abstract

Group 3 innate lymphocytes (ILC3s) are rare immune cells localized in mucosal tissues, especially the gastrointestinal (GI) tract. Despite their rarity, they are a major source of the cytokine interleukin-22 (IL-22), which protects the GI epithelium during inflammation and infection.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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