Biological Evaluation of the Antibacterial Retinoid CD437 in Cutibacterium acnes Infection-Reference-Cited by-同舟云学术

Biological Evaluation of the Antibacterial Retinoid CD437 in Cutibacterium acnes Infection

Published:2023-04-18 Issue:4 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Huang Xiao-wen¹,Pan Wen²^ORCID,Zhong Mei-zhen¹,Chhonker Yashpal Singh³,Steele Andrew D.⁴,Keohane Colleen E.⁴,Mishra Biswajit²,Felix Raj Lucas Lewis Oscar²,Murry Daryl J.³^ORCID,Ausubel Frederick M.⁵⁶,Wuest William M.⁴⁷,Li Chang-xing¹,Mylonakis Eleftherios²⁸^ORCID

Affiliation:

1. Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China

2. Division of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

3. Department of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, USA

4. Department of Chemistry, Emory University, Atlanta, Georgia, USA

5. Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA

6. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA

7. Emory Antibiotic Resistance Center, Emory University, Atlanta, Georgia, USA

8. Department of Medicine, Houston Methodist Hospital and Academic Institute, Houston, Texas, USA

Abstract

Acne vulgaris is a complex skin disease involving infection by Cutibacterium acnes , inflammation, and hyperkeratinization. We evaluated the activity of the retinoid 6-[3-(adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) and 16 other retinoid analogs as potential anti- C. acnes compounds and found that CD437 displayed the highest antimicrobial activity with an MIC against C. acnes (ATCC 6919 and HM-513) of 1 μg/mL.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01679-22

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