Genomic Profiling of Evolving Daptomycin Resistance in a Patient with Recurrent Staphylococcus argenteus Sepsis-Reference-Cited by-同舟云学术

Genomic Profiling of Evolving Daptomycin Resistance in a Patient with Recurrent Staphylococcus argenteus Sepsis

Published:2020-09-21 Issue:10 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hao Samantha¹^ORCID,Abdelghany Mazin²,Lyden Amy¹,Sit Rene¹,Tan Michelle¹,Tato Cristina M.¹,DeRisi Joseph L.¹³^ORCID,Miller Steve⁴^ORCID,Doernberg Sarah B.²,Langelier Charles¹²^ORCID

Affiliation:

1. Chan Zuckerberg Biohub, San Francisco, California, USA

2. Division of Infectious Diseases, Department of Medicine, University of California San Francisco, San Francisco, California, USA

3. Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA

4. Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA

Abstract

Staphylococcus argenteus is a novel staphylococcal species associated with invasive disease. We report the first case of daptomycin/vancomycin-resistant S. argenteus , initially speciated as Staphylococcus aureus , that developed from repeated treatment with daptomycin for a complex vascular graft infection. Whole-genome sequencing of longitudinally collected isolates identified acquisition of MprF S337L, a mutation predicted to increase surface charge and repel cationic molecules.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00961-20

Reference12 articles.

1. Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance

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3. A Very Early-Branching Staphylococcus aureus Lineage Lacking the Carotenoid Pigment Staphyloxanthin