Changes in Helicobacter pylori ultrastructure and antigens during conversion from the bacillary to the coccoid form

Author:

Benaissa M1,Babin P1,Quellard N1,Pezennec L1,Cenatiempo Y1,Fauchère J L1

Affiliation:

1. Laboratoire de Microbiologie A, Centre Hospitalier Regional Universitaire-La Miletrie, Poitiers, France.

Abstract

In vitro, Helicobacter pylori converts from a bacillary to a full coccoid form via an intermediate U-shaped form. Organisms with a full coccoid form keep a double membrane system, a polar membrane, and invagination structures. Western blots (immunoblots) of sera from colonized patients show that some high-molecular-mass antigenic fractions are expressed only in coccoids. Conversely, fractions of 30 and 94 kDa were more intensively detected in the bacillary forms. These results suggest that (i) coccoid conversion is not a degenerative transformation and (ii) antigens specific to the coccoid forms are expressed in vivo.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference28 articles.

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