Regulation of Mumps Virus Replication and Transcription by Kinase RPS6KB1-Reference-Cited by-同舟云学术

Regulation of Mumps Virus Replication and Transcription by Kinase RPS6KB1

Published:2020-06 Issue:12 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Briggs Kelsey¹,Wang Leyi¹,Nagashima Kaito¹,Zengel James¹,Tripp Ralph A.¹^ORCID,He Biao¹

Affiliation:

1. Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA

Abstract

Mumps virus is an important human pathogen. In recent years, MuV has reemerged in the United State, with outbreaks occurring in young adults who have been vaccinated. Our work provides insight into a previously unknown mumps virus-host interaction. RPS6KB1 negatively regulates MuV replication, likely through its interaction with the P protein. Understanding virus-host interactions can lead to novel antiviral drugs and enhanced vaccine production.

Funder

Endowment of Fred C. Davison Distinguished University Chair

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00387-20

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