Human AdV-20-42-42, a Promising Novel Adenoviral Vector for Gene Therapy and Vaccine Product Development

Author:

Ballmann Mónika Z.1,Raus Svjetlana2,Engelhart Ruben12,Kaján Győző L.3,Beqqali Abdelaziz2,Hadoke Patrick W. F.2,van der Zalm Chantal1,Papp Tibor4,John Lijo3,Khan Selina4,Boedhoe Satish4,Danskog Katarina3,Frängsmyr Lars3,Custers Jerome4,Bakker Wilfried A. M.1ORCID,van der Schaar Hilde M.1,Arnberg Niklas3,Lemckert Angelique A. C.1,Havenga Menzo1,Baker Andrew H.2ORCID

Affiliation:

1. Batavia Biosciences B.V., Leiden, The Netherlands

2. Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, United Kingdom

3. Department of Clinical Microbiology, Division of Virology, Umeå University, Umeå, Sweden

4. Janssen Vaccines and Prevention B.V., Leiden, The Netherlands

Abstract

Adenoviral vectors are under investigation for a broad range of therapeutic indications in diverse fields, such as oncology and gene therapy, as well as for vaccination both for human and veterinary use. A wealth of data shows that preexisting immune responses may limit the use of a vector.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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